Effects of the Rho-Kinase Inhibitor, Fasudil, on Pulmonary Hypertension
نویسندگان
چکیده
منابع مشابه
Effects of the Rho-kinase inhibitor, fasudil, on pulmonary hypertension.
motility, migration, proliferation, differentiation, and apoptosis. Activation of Rho/ROCK is considered to play a major role in the pathogenesis of several cardiovascular diseases, including PH,5 and thus is a new therapeutic target for PH (Figure). Fasudil is one of the most frequently used ROCK inhibitors, and was approved as a therapeutic agent for vasospasm after arachnoid hemorrhage. Seve...
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Current pharmacological interventions for pulmonary arterial hypertension (PAH) require continuous infusions, multiple inhalations, or oral administration of drugs that act on various pathways involved in the pathogenesis of PAH. However, invasive methods of administration, short duration of action, and lack of pulmonary selectivity result in noncompliance and poor patient outcomes. In this stu...
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BACKGROUND We investigated the acute vasodilator effects of i.v. fasudil, a specific Rho-kinase inhibitor, on pulmonary circulation in patients with congenital heart defects (CHD) and severe pulmonary arterial hypertension (PAH). METHODS AND RESULTS Thirty-five patients (34.23±12.10 years old) with CHD and severe PAH were consecutively enrolled. All patients underwent heart catheterization. A...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2015
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-15-0443